Mark Kittisopikul, Ph.D.

Quantitative Biologist

Professional Experience


2022 - Present Software Engineer II, Computational Methods, Janelia Research Campus, HHMI, Ashburn, VA

2020 - 2022 Scientific Computing Associate II, Computational Methods, Janelia Research Campus, HHMI, Ashburn, VA

Project: Computational methods for next-generation light-sheet microscopy with the Lab of Philipp J. Keller

2017-2020 Postdoctoral Fellow, Lab of Robert D. Goldman, Northwestern University, Chicago, IL

Project: Studied lamin-nuclear pore complex interactions using super-resolution light microscopy and image analysis

2014-2020 Postdoctoral Fellow, Lab of Khuloud Jaqaman, University of Texas Southwestern Medical Center, Dallas, TX

Project: Developed image analysis routines to localize lamin fibers in super-resolution light micrographs

Education

2006-2014 Ph.D., Molecular Biophysics, Lab of Gürol Süel, University of Texas Southwestern Medical Center, Dallas, TX

Project: Studied single cell and community interactions of B. subtilus using synthetic biology and computational modeling

2002-2006 B.S. , Biological Chemistry, Mathematics, University of Chicago, Chicago, IL

Project: Studied phospholipid thermodynamics (Prof. Ka Yee C. Lee); Simulated immulogical synapse (Prof. Aaron Dinner)

Selected Publications

Kittisopikul M, Shimi T, Tatli M, Tran JR, Zheng Y, Medalia O, Jaqaman K, Adam SA, Goldman RD. Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins. J Cell Biol. 2021 Apr 5;220(4):e202007082. doi: 10.1083/jcb.202007082. PMID: 33570570; PMCID: PMC7883741.

Kittisopikul M
, Vahabikashi A, Shimi T, Goldman RD, Jaqaman K. Adaptive multiorientation resolution analysis of complex filamentous network images. Bioinformatics. 2020 Dec 22;36(20):5093-5103. doi: 10.1093/bioinformatics/btaa627. PMID: 32653917.

Chang BJ, Kittisopikul M*, Dean KM, Roudot P, Welf ES, Fiolka R. Universal light-sheet generation with field synthesis. Nat Methods. 2019 Mar;16(3):235-238. doi: 10.1038/s41592-019-0327-9. Epub 2019 Feb 25. PMID: 30804550; PMCID: PMC6561754.

Shimi T, Kittisopikul M*, Tran J, Goldman AE, Adam SA, Zheng Y, Jaqaman K, Goldman RD. Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy. Mol Biol Cell. 2015 Nov 5;26(22):4075-86. doi: 10.1091/mbc.E15-07-0461. Epub 2015 Aug 26. PMID: 26310440; PMCID: PMC4710238.

Asally M, Kittisopikul M, Rué P, Du Y, Hu Z, Çağatay T, Robinson AB, Lu H, Garcia-Ojalvo J, Süel GM. Localized cell death focuses mechanical forces during 3D patterning in a biofilm. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18891-6. doi: 10.1073/pnas.1212429109. Epub 2012 Sep 24. PMID: 23012477; PMCID: PMC3503208.

Kittisopikul M, Süel GM. Biological role of noise encoded in a genetic network motif. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13300-5. doi: 10.1073/pnas.1003975107. Epub 2010 Jun 28. PMID: 20616054; PMCID: PMC2922135.

*Co-First Author

Full Bibliography: https://orcid.org/0000-0002-9558-6248 , https://scholar.google.com/citations?user=eWwcvf0AAAAJ